Figure 1 | Scientific Reports

Figure 1

From: Gene Expression Analyses in Non Muscle Invasive Bladder Cancer Reveals a Role for Alternative Splicing and Tp53 Status

Figure 1

(A) Differential gene expression between normal and bladder cancer samples using Affymetrix HuGene-1_0-st-v1 arrays. (B) Gene Ontology Biological Processes (GOBP) analyses of the transcripts showing statistically significant differences. (C) Genesets often de-regulated in cancer that overlaps with the genesets showing differences between normal and tumor samples using the Molecular Signatures Database (MSigDB) from GSEA software. (D) Those de-regulated genes share binding motifs for MYC and E2Fs transcription factors, according with ChEA, Transfac, and Encode Transcription Factor databases. (E) Genes whose expression is correlated with the expression of the ESRP2 splicing factor. (F) Genes whose expression is correlated with the expression of the PRMT5 splicing factor. (G) Genes whose expression is correlated with the expression of the RBM4 splicing factor.

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