Figure 3
Esketamine-sensitive within- and inter-network dynamic rsFC connections, revealed after compartmentalization into Yeo networks. Connections for which NBS31 showed a negative influence of esketamine on dynamic rsFC were compartmentalized into networks based on Yeo et al.32 and three additional regions (amygdala/hippocampus, basal ganglia, cerebellum, based on the Harvard-Oxford atlas). This figure depicts connections within and between these networks/regions (Yeo/Harvard-Oxford), split for each methodological approach (exponentially weighted sliding-window correlation method based on Zalesky et al.25, MTD based on Shine et al.26), atlas (Craddock et al.29, Power et al.30), and statistic (intensity: strength of connections, extent: number of connections). Esketamine plasma levels had a significant negative influence on dynamic rsFC in comparison to placebo for the connections between LVI and RVI and within the LVI, regardless of dynamic rsFC estimation method. For a list of connections see Table S1. Orange, green, and blue lines reflect connections within networks of the same hemisphere, inter-hemispheric connections within the same network, and inter-hemispheric connections to another network, respectively. Line thickness reflects intensity/extent statistics, depending on the subfigure. rVI/lVI: right/left visual network,* rSM/lSM: right/left somato-motor network,* rDA/lDA: right/left dorsal attention network,* rVA/lVA: right/left ventral attention network,* rFT/lFT: right/left fronto-temporal network,* rFP/lFP: right/left fronto-parietal network,* rDM/lDM: right/left default mode network,* rHI/lHI: right/left amygdala/hippocampus** (not included in the Power parcellation30), rBG/lBG: right/left basal ganglia,** rCE/lCE: right/left cerebellum**. *Networks based on Yeo et al.32, **Regions based on Harvard-Oxford atlas.
