Table 2 Individual connections for which NBS revealed a negative influence of esketamine on dynamic rsFC across all methodological approaches.

From: Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks

Craddock atlas

Coordinates

Regions (AAL)

Network

−68/−28/0

64/−24/16

Mid. temporal gyrus (l)

Sup. temporal gyrus (r)

lDM-rSM

64/−24/16

−48/−32/0

Sup. temporal gyrus (r)

Mid. temporal gyrus (l)

rSM-lDM

20/−76/−4

−32/−88/12

Lingual gyrus (r)

Mid. occipital gyrus (l)

rVI-lVI

−32/−88/12

−8/60/28

Mid. occipital gyrus (l)

Sup. med. frontal gyrus (l)

lVI-lDM

20/−76/−4

28/−96/0

Lingual gyrus (r)

Inf. occipital cortex (r)

rVI-rVI

−20/−96/−8

−20/−72/−8

Inf. occipital cortex (l)

Lingual gyrus (l)

lVI-lVI

20/−76/−4

−20/−72/−8

Lingual gyrus (r)

Lingual gyrus (l)

rVI-lVI

28/−96/0

−20/−72/−8

Inf. occipital cortex (r)

Lingual gyrus (l)

rVI-lVI

8/−100/−8

−20/−72/−8

x

Lingual gyrus (l)

rVI-lVI

−48/−32/0

64/−24/−12

Mid. temporal gyrus (l)

Mid. temporal gyrus (r)

lDM-rDM

−16/−64/28

0/0/−8

Sup. occipital region (l)

x

lVI-rBG

64/−24/16

0/0/−8

Sup. temporal gyrus (r)

x

rSM-rBG

20/−76/−4

−40/−84/−12

Lingual gyrus (r)

Inf. occipital cortex (l)

rVI-lVI

−68/−28/0

44/12/−16

Mid. temporal gyrus (l)

Sup. temporal pole (r)

lDM-rDM

−8/60/28

48/−80/8

Sup. med. frontal gyrus (l)

Mid. occipital gyrus (r)

lDM-rVI

−32/−88/12

12/−100/16

Mid. occipital gyrus (l)

x

lVI-rVI

28/−96/0

12/−100/16

Inf. occipital cortex (r)

x

rVI-rVI

−40/−84/−12

12/−100/16

Inf. occipital cortex (l)

x

lVI-rVI

20/−76/−4

−8/−84/−28

Lingual gyrus (r)

Crus 2 cerebellum (l)

rVI-lCE

8/−100/−8

−8/−84/−28

x

Crus 2 cerebellum (l)

rVI-lCE

Power atlas

Coordinates

Regions (AAL)

Network

−24.66/−97.84/−12.33

24.41/−87.21/24.01

x

Sup. occipital region (r)

lVI-rVI

7.98/−91.08/−7.10

−40.21/−88.44/−6.19

Lingual gyrus (r)

Mid. occipital gyrus (l)

rVI-lVI

  1. Illustrates individual region to region connections for which NBS31 showed that esketamine had a significant negative influence on dynamic rsFC regardless of which methodological approach was used. Coordinates from the Craddock and Power atlases were translated to AAL and corresponding Yeo networks are noted to improve interpretability.
  2. AAL = Automated Anatomical Labeling atlas.
  3. x = coordinates from Craddock atlas29 or Power atlas30, but not denoted in AAL.
  4. rVI/lVI: right/left visual network,*
  5. rSM/lSM: right/left somato-motor network,*
  6. rDM/lDM: right/left default mode network,*
  7. rBG/lBG: right/left basal ganglia,**
  8. rCE/lCE: right/left cerebellum**.
  9. *Networks based on Yeo et al.32, **Regions based on Harvard-Oxford atlas.