Table 2 Association of GCKR rs780094-T with lipids.

From: An intronic variant in the GCKR gene is associated with multiple lipids

Pathway

Beta

P value

P* value

Sub class

Direct parent

Novel

Glycerolipids

Triacylglycerides*

0.107

2.1E-14

1.6E10-16

TAG

TAG

No

Palmitoleoyl-linoleoyl-glycerol (16:1/18:2) (1)**

0.109

3.8E-09

6.9E10-10

DAG

1,2-DAG

Yes

Myristoyl-linoleoyl-glycerol (14:0/18:2) (1)**

0.120

7.4E-11

2.2E10-11

DAG

1,2-DAG

Yes

Palmitoyl-linoleoyl-glycerol (16:0/18:2) (2)**

0.057

4.9E-05

2.4E10-5

DAG

1,2-DAG

Yes

Oleoyl-linoleoyl-glycerol (18:1/18:2) (1)**

0.065

3.4E-06

1.3E10-6

DAG

1,2-DAG

Yes

Oleoyl-linoleoyl-glycerol (18:1/18:2) (2)**

0.061

1.1E-05

4.9E10-6

DAG

1,2-DAG

Yes

DAG (12:0/18:1, 14:0/16:1, 16:0/14:1) (2)**

0.091

9.0E-07

3.0E10-7

DAG

1,2-DAG

Yes

Oleoyl-arachidonoyl-glycerol (18:1/20:4) (1)**

0.095

3.1E-07

8.0E10-8

DAG

1,2-DAG

Yes

Oleoyl-arachidonoyl-glycerol (18:1/20:4) (2)**

0.087

2.4E-06

9.5E10-7

DAG

1,2-DAG

Yes

Oleoyl-oleoyl-glycerol (18:1/18:1) (2)**

0.087

2.7E-06

7.7E10-7

DAG

1,2-DAG

Yes

1-palmitoleoylglycerol (16:1)

0.082

1.6E-07

4.4E10-8

MAG

1-MAG

Yes

1-oleoylglycerol (18:1)

0.057

5.0E-05

3.2E10-5

MAG

1-MAG

Yes

1-myristoylglycerol (14:0)

0.073

2.0E-07

9.8E10-8

MAG

1-MAG

Yes

Glycerophospholipids

1-stearoyl-2-arachidonoyl-GPI (18:0/20:4)

0.058

3.5E-05

1.2E10-5

GPI

PI

Yes

1-palmitoyl-2-oleoyl-GPE (16:0/18:1)

0.085

1.3E-09

4.0E10-10

GPE

PE

Yes

1-palmitoyl-2-docosahexaenoyl-GPE (16:0/22:6)

0.087

2.1E-08

1.2E10-8

GPE

PE

Yes

1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6)

0.098

3.1E-10

6.1E10-11

GPE

PE

Yes

1-palmitoyl-2-linoleoyl-GPE (16:0/18:2)

0.063

6.6E-06

7.7E10-6

GPE

PE

Yes

1-stearoyl-2-oleoyl-GPE (18:0/18:1)

0.075

9.0E-08

1.7E10-8

GPE

PE

Yes

1-stearoyl-2-linoleoyl-GPE (18:0/18:2)

0.07

5.0E-07

2.2E10-6

GPE

PE

Yes

1-stearoyl-2-arachidonoyl-GPE (18:0/20:4)

0.064

4.2E-06

1.2E10-6

GPE

PE

Yes

1-oleoyl-2-docosahexaenoyl-GPE (18:1/22:6)

0.082

1.0E-05

6.3E10-6

GPE

PE

Yes

1-oleoyl-2-arachidonoyl-GPE (18:1/20:4)

0.078

2.7E-05

3.8E10-5

GPE

PE

Yes

1-stearoyl-GPE (18:0)

0.077

3.6E-08

3.0E10-8

GPE

Lyso-PEth

Yes

1-palmitoyl-GPE (16:0)

0.068

1.2E-06

2.7E10-6

GPE

Lyso-PEth

Yes

1-myristoyl-2-arachidonoyl-GPC (14:0/20:4)

0.092

3.0E-09

2.9E10-10

GPC

PC

Yes

1-myristoyl-2-palmitoyl-GPC (14:0/16:0)

0.065

2.9E-05

2.1E10-5

GPC

PC

Yes

1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1)

0.064

5.1E-06

9.8E10-7

GPC

PC

Yes

1-palmitoleoyl-GPC (16:1)

0.065

3.5E-06

1.1E10-6

GPC

Lyso-PCho

Yes

1-(1-enyl-palmitoyl)-2-palmitoleoyl-GPC (P-16:0/16:1)

-0.070

4.8 E-07

1.6E10-7

GPC

PlCho

Yes

1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2)

-0.069

9.7 E-07

1.6E10-7

GPC

PlCho

Yes

1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1)

-0.063

5.9E-06

1.1E10-6

GPC

PlCho

Yes

Sphingolipids

lactosyl-N-nervonoyl-sphingosine (d18:1/24:1)

-0.081

1.1E-05

2.7E10-6

GSL

Lactosylceramide

Yes

lactosyl-N-palmitoyl-sphingosine (d18:1/16:0)

-0.061

1.3E-05

2.8E10-6

GSL

Lactosylceramide

Yes

  1. Abbreviations: DAG, Diacylglycerol; GPC, Glycerophosphocoline; GPE, Glycerophosphoethanolamine; GPI, Glycerophosphoinositol; GSL, Glycerosphingolipid; Lyso-PCho, Lysophosphatidylcholine; Lyso-PEth, Lysophosphatidylethanolamine; MAG, Monoacylglycerol; PC, Phosphatidylcholine; PE, Phosphatidylethanolamine; PI, Phosphatidylinositol; PlCho, Plasmalogen-Choline; TAG, Triacylglycerol.
  2. *TAG was measured using an enzymatic method.
  3. Beta and P-values were obtained from linear regression.
  4. P-value*: P value adjusted for batch effect, age and fasting glucose.
  5. **The numbers (1) and (2) in parentheses refer to different stereoisomers of the metabolites.
  6. Abbreviations: DAG, Diacylglycerol; GPC, Glycerophosphocoline; GPE, Glycerophosphoethanolamine; GPI, Glycerophosphoinositol; GSL, Glycerosphingolipid; Lyso-PCho, Lysophosphatidylcholine; Lyso-PEth, Lysophosphatidylethanolamine; MAG, Monoacylglycerol; PC, Phosphatidylcholine; PE, Phosphatidylethanolamine; PI, Phosphatidylinositol; PlCho, Plasmalogen-Choline; TAG, Triacylglycerol.
  7. *TAG was measured using an enzymatic method. **The numbers (1) and (2) in parentheses refer to different stereoisomers of the metabolites. Only metabolites that were associated significantly (P < 5.8 × 10−5) with GCKR rs780094-T are shown. Beta and P values were obtained from linear regression, and were adjusted for batch effect, P* values were adjusted for batch effect, age and fasting glucose.
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