Table 5 Cox proportional hazards models analysis of potential prognostic factors affecting PFS.

From: Prognostic Significance of Metabolic Parameters and Textural Features on 18F-FDG PET/CT in Invasive Ductal Carcinoma of Breast

 

Univariate analysis

Multivariate analysis

HR (95% CI)

p

HR (95% CI)

p

Age (<vs. ≥50 years)

0.76 (0.28–2.52)

0.7641

  

Laterality (Right vs. Left)

1.18 (0.39–3.54)

0.7655

  

Differentiation

2.24 (0.85–5.90)

0.1038

  

Tumor size (≥vs.<3.5 cm)

5.59 (1.63–19.16)

0.0062*

  

N status (positive vs. negative)

3.62 (1.14–11.46)

0.0188*

  

Number of LN (≥vs.<5)

3.50 (1.10–11.05)

0.0332*

  

M status (+ vs.−)

3.65 (1.15–11.56)

0.0275*

  

Clinical stage

2.12 (1.19–3.77)

0.0053*

  

ER (positive vs. negative)

0.50 (0.16–1.54)

0.2268

  

PR (positive vs. negative)

0.43 (0.14–1.32)

0.1392

  

c-erbB-2 (positive vs. negative)

1.64 (0.55–4.92)

0.3708

  

p53 (positive vs. negative)

0.40 (0.11–1.41)

0.1529

  

Ki-67 (≥vs.<25%)

2.48 (0.26–24.04)

0.4335

  

Maximal SUVbt (≥vs.<4.0)

3.06 (0.99–9.45)

0.0467*

  

Maximal SUVln (≥vs.<1.3)

3.23 (0.88–11.83)

0.0765

  

MTVbt (≥vs.<35.6 cm3)

7.50 (1.65–34.07)

0.0091*

  

MTVwb (≥vs.<115.4 cm3)

11.77 (3.54–39.1)

0.0001*

8.29 (2.17–31.64)

0.0020*

TLGbt (≥vs.<205.9 cm3)

4.02 (1.34–12.07)

0.0131*

  

TLGwb (≥vs.<232.7 cm3)

6.60 (2.04–21.37)

0.0017*

  

Contrast (≥vs.<185190)

5.04 (1.59–12.15)

0.0001*

  

Homogeneity (≥vs.<268.7)

9.22 (1.19–71.29)

0.0334*

  

Dissimilarity (≥vs.<15958)

14.80 (1.9–115.1)

0.0100*

  

Second angular moment (≥vs.<20654)

3.60 (1.17–11.07)

0.0251*

  

SUVbt skewness (≥vs.<1.20)

0.52 (0.17–1.56)

0.2412

  

SUVbt kurtosis (≥vs.<2.82)

5.04 (0.66–38.90)

0.1202

  

SUVbt variance (≥vs.<0.50)

2.46 (0.82–7.35)

0.1080

  

SUVbt mean (≥vs.<1.89)

3.49 (1.16–10.47)

0.0260*

  

SUVbt entropy (≥vs.<3.51)

2.84 (0.87–9.34)

0.0852

  
  1. *Statistically significant.
  2. ER: estrogen receptor.
  3. PR: progesterone receptor.
  4. c-erbB-2: human epidermal growth factor receptor 2.
  5. SUVbt: standardized uptake value of breast tumor.
  6. SUVln: standardized uptake value of axillary lymph node.
  7. MTVbt: metabolic tumor volume of breast tumor.
  8. MTVwb: metabolic tumor volume of whole body lesions.
  9. TLGbt: total lesion glycolysis of breast tumor.
  10. TLGwb: total lesion glycolysis of whole body lesions.
  11. HR: hazard ratio; CI: confidence interval.
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