Figure 1 | Scientific Reports

Figure 1

From: Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants

Figure 1

Gene expression profiling data for CALRwt, CALRdel52 and CALRins5 K562 cells. (A) The Principal component analysis was performed by using the PCA module implemented in Partek GS. wt-transduced K562 are shown in blue, while CALRdel52 and CALRins5-transduced K562 are shown in red. Mutational status (i.e.wt, CALRdel52 and CALRins5) is indicated by using different shapes. (B) Hierarchical clustering and heat map analysis for the transcripts differentially expressed in both CALRdel52 and CALRins5-transduced cells vs wt-transduced cells using a gene list having an unadjusted p-value <0.01 in the ANOVA analysis. For each transcript, red bars indicate relatively high signal intensity, while green bars represent lower intensity and black intermediate. The clustering of the samples is indicated by the dendrogram on the top.

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