Table 2 Circulating miRNAs associated with clinical characteristics.

From: Circulating microRNAs as Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma

 

MiRNA

Non-Tumor Liver

General

Tumor

 

Steatosis

Cirrhosis

AST

AFP

Viral Infection

Tumor Size

Tumor Invasion

Multifocality

Survival

Fold change (Present/Absent)

p-value*

Fold change (Present/Absent)

p-value*

Rank correlation coefficient

p-value*

Rank correlation coefficient

p-value*

Fold change (Present/Absent)

p-value

Rank correlation coefficient

p-value

Fold change (Present/Absent)

p-value*

Fold change (Multi-/Single-nodal)

p-value

Hazard Ratio

p-value*

1

miR-214-3p

−3.96

1.78 × 10−2

                

2

miR-95

−3.36

3.52 × 10−5

                

3

miR-451a

  

3.42

1.31 × 10−2

  

−0.46

9.05 × 10−8

          

4

miR-222-3p

  

1.64

1.33 × 10−2

              

5

miR-483-5p

  

−2.29

3.75 × 10−3

  

0.46

2.95 × 10−6

          

6

miR-574-3p

  

−2.16

1.27 × 10−4

              

7

miR-193a-5p

  

−2.06

1.31 × 10−2

              

8

miR-152

  

−1.56

3.75 × 10−3

              

9

miR-423-3p

      

0.31

5.12 × 10−4

          

10

miR-221-3p

      

0.23

1.23 × 10−2

          

11

let-7b-5p

      

−0.34

8.84 × 10−5

          

12

miR-301a-3p

      

−0.23

1.30 × 10−2

          

13

miR-34a-5p

    

0.34

2.75 × 10−2

            

14

miR-29a-3p

    

0.31

2.75 × 10−2

            

15

miR-22-5p

    

0.31

2.75 × 10−2

            

16

let-7a-5p

            

2.00

4.11 × 10−2

    

17

miR-320d

            

1.59

3.58 × 10−2

    

18

miR-423-5p

            

1.56

3.58 × 10−2

    

19

miR-410

      

0.32

2.27 × 10−3

1.71

2.11 × 10−2

      

1.79

9.42 × 10−3

20

miR-382-5p

      

0.24

1.74 × 10−2

  

0.21

4.53 × 10−2

    

1.64

9.42 × 10−3

21

miR-139-5p

            

1.62

3.34 × 10−2

1.58

3.15 × 10−2

1.77

9.42 × 10−3

22

miR-128

          

0.20

4.63 × 10−2

1.47

4.84 × 10−2

  

2.35

9.65 × 10−3

23

miR-101-3p

          

−0.24

1.72 × 10−2

−2.19

3.50 × 10−2

  

0.75

9.42 × 10−3

24

miR-424-5p

        

−1.66

1.24 × 10−2

−0.22

2.85 × 10−2

−1.87

7.12 × 10−3

  

0.69

9.65 × 10−3

  1. *Bold indicates corrected p-values that are < 0.05 i.e. these miRNAs show statistically significant association after multiple test corrections, while non-bold shows p-values before multiple test correction.
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