Figure 1
From: Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm
Transient elastase perfusion induces AAA. Mice were transiently perfused with elastase on day 0 and increase in aortic diameter (AD) was measured immediately post-perfusion, and on day 7 or day 14. Elastase perfusion resulted in ∼70% increase in AD on day 0 (post perfusion). AAA was defined as an increase in AD of greater than 100% on day 14 compared with the AD measured prior to elastase perfusion. AAA is expressed as the increase in AD in mm (A) or % (B). AAA was accompanied by elastic fiber degradation on day 14 (C). Scale bar = 250 um.
