Figure 6
A schematic representation of the organization of proteins associating with MAP3K4. The figure represents the proposed model for HER2/HER3 signaling in breast cancer cells. HER3 heterodimerizes with HER2 upon HRG binding to HER3. The catalytic domain of HER2 auto phosphorylates and phosphorylates HER3 on tyrosine 1289 and tyrosine 1329, among others. MAP3K4, actin, and GIT1 are recruited to HER345. HER2/HER3 signaling results in GIT1 mediated increased extracellular acidification. Additionally, HER2/HER3 signaling results in reduced expression of GPR81 mRNA.
