Figure 6
From: The Role of Conformational Dynamics in Abacavir-Induced Hypersensitivity Syndrome
Key HLA-B*57:01 residues and their conformation relative to that of abacavir. HLA-B*57:01 is shown in gray cartoon with residues Ile 95, Val97, Asp114, Ser116, and Tyr123 shown in yellow sticks. Abacavir is shown in deep purple sticks and the pepV peptide pepV in orange sticks. The MHC α2 helix has been omitted for clarity. (A) The starting frame from run1, and a conformation from each of the independent replicates (B) run1, (C) run2, and (D) run3 are shown, illustrating how abacavir does not maintain a consistent position or orientation with respect to these residues.
