Table 2 Partial peptide detachment and number and location of abacavir or abacavir-analogue escapes from the antigen-binding cleft.
From: The Role of Conformational Dynamics in Abacavir-Induced Hypersensitivity Syndrome
Peptide | Analogue | Partial peptide detachment | Number of escapes | Location of escape |
|---|---|---|---|---|
3UPR | abacavir | C-terminus | 1 | C-terminus |
carbovir | 0 | |||
didanosine | N-terminus | 2 | N-terminus; centre of cleft | |
guanosine | 0 | |||
3VRI | abacavir | 0 | ||
carbovir | N-terminus | 1 | N-terminus | |
didanosine | C-terminus | 2 | C-terminus; centre of cleft | |
guanosine | 1 | Centre of cleft | ||
3VRJ | abacavir | 0 | ||
carbovir | 0 | |||
didanosine | 0 | |||
guanosine | 0 |
