Figure 5
XL765 treatment increases animal survival without apparent tumor volume difference. (A) Axial T2-weighted images at D0 (first column) and D15 of treatment (second column) for control (top) and XL765-treated (bottom) U87IDHmut-tumor bearing mice brains. Tumor regions are contoured with a white line and the square box at D15 depicts the 1H-MRS voxel. Day 15 was the final day for both presented mice. Mice were treated with 30 mg/kg XL765 twice daily p.o. or with 10 mM HCl (control group). (B) Temporal evolution of average tumor volume normalized to D0. (*p < 0.05, ***p < 0.001, n.s.: not significant) (C) Kaplan–Meier survival curves comparing survival between XL765-treated animals (light gray line) and control (dark purple line) ones. (D) Representative spectra of a control animal, its LCModel fit and residual of the fit. Apodization of 5 Hz has been applied. Numbers indicate the following metabolites: 1. Lipids, 2. Lactate and Lipids, 3. Alanine, 4. N-acetylaspartate, 5. 2HG, 6. Glutamate and Glutamine, 7. Aspartate, 8. Total creatine, 9. Total choline and 10. Myo-Inositol.
