Figure 8
From: USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells
The colocalization of USP10 with pTau aggregates in AD brain regions. (a,b) Representative immunohistochemical findings of USP10 and pTau in temporal cortex of AD patients (n = 3) are shown. The colocalization of USP10 with pTau aggregates was analyzed by a line profile analysis. Arrows indicate the colocalization suggested by the assay. The relative staining levels of USP10 and pTau on the indicated line were presented (b). Lower magnification pictures were presented in Supplementary Fig. S6. (c) The current working model for pathogenic Tau aggregation through SGs and aggresomes.
