Table 1 Lack of detectable positive selection in the k13 gene using codon substitution models.

From: Comparative structural and evolutionary analyses predict functional sites in the artemisinin resistance malaria protein K13

Models

Purpose of the test

2Δℓ

df

p value

M0-FR

Heterogeneity of ω among lineages of the phylogenetic tree

457.0

82

1.9 × 10−53

M0-M3

Heterogeneity of ω across codon sites

1,046.3

4

3.3 × 10−225

M1a-M2a

Detection of sites evolving under positive selection

0

2

1

M7-M8

Detection of sites evolving under positive selection

0

2

1

  1. ω, non-synonymous (dN) to synonymous (dS) substitution rate ratio (dN/dS); 2∆ℓ, log-likelihood ratio of the two tested models; df, degrees of freedom. 2Δℓ was compared to a chi-squared table to determine the significance of the likelihood ratio tests. The M1a-M2a comparison is reported to be more stringent than the M7-M8 comparison34.
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