Figure 1
Design of latent interferon alpha 2b fused with LAP domain of human TGFβ via HCV NS3 protease cleavage site as linker. (A) Linear sequence of IFNα2b fused with LAP in both conformations. (B) Putative folding of fusion proteins showing formation of intermolecular disulfide bridge between cysteine residue 224 and 226 to confer latency to IFNα2b.
