Figure 2 | Scientific Reports

Figure 2

From: Quantitative Mass Spectrometry Imaging Reveals Mutation Status-independent Lack of Imatinib in Liver Metastases of Gastrointestinal Stromal Tumors

Figure 2

Verification of MALDI-TOF-qMSI for imatinib quantification in GIST. Comparison of MALDI-TOF-qMSI and UPLC-ESI-QTOF-MS quantification for (a) normal and (b) tumor tissue. (c) A liver metastasis (sample J) illustrating the drug-containing pixels (bottom) and corresponding H&E-stained image (top). (d) A correlation plot showing MALDI-TOF-qMSI on the x-axis and UPLC-ESI-QTOF-MS on the y-axis, both log2-scaled. The dashed red line represents an identity line (1:1 line) with the log2 fold change of 1 represented by the grey area around it. (e) Comparison of MALDI-TOF-qMSI, UPLC-ESI-QTOF-MS and MALDI-FTICR-qMSI quantification for five (x3) unaffected liver samples.

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