Figure 8
From: Modeling the binding of diverse ligands within the Ah receptor ligand binding domain
Relative binding affinity for group 1, 2 and 3 ligands relative to wild-type and mutant AhRs. The relative affinity (−logIC50) of each test chemical for the AhR ligand was determined from concentration-dependent inhibition curves obtained using [3H]TCDD ligand binding analysis, as described under Materials and Methods. The mean IC50 ± standard deviation was determined using three-parameter non-linear regression of nine independent reactions. (*) Represents a significant (p ≤ 0.05) change in ligand binding affinity relative to wild-type mAhR in One-Way ANOVA Multiple Comparison Test.
