Table 2 Partial correlation meta-analysis results of LTL and metabolites (p-value in model 1 < 0.05).

From: Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

Metabolite

Model 1: age + sex

Model 2: age + sex + BMI

Metabolite full name

n

direction*

r

p-value

FDR

n

direction*

r

p-value

FDR

lysoPC a C17:0

7853

++−++++

0.05

7.1 × 10 −6

9.3 × 10−4

7638

++−+++

0.04

4.7 × 10 −4

6.9 × 10−3

Lysophosphatidylcholine acyl C17:0

Met

7852

−−−−−−+

−0.04

9.2 × 10 −5

6.0 × 10−3

7637

−−−−−−

−0.05

7.5 × 10 −5

9.3 × 10−4

Methionine

Tyr

7047

−−−−?−+

−0.04

2.1 × 10 −4

6.9 × 10−3

6832

−−−−?−

−0.04

8.9 × 10 −4

6.9 × 10−3

Tyrosine

PC aa C32:1

7851

−−−−+−+

−0.04

2.4 × 10 −4

6.9 × 10−3

7636

−−−−++

−0.04

3.4 × 10 −4

6.9 × 10−3

Phosphatidylcholine diacyl C32:1

C3-OH

1449

????−−?

−0.10

2.6 × 10 −4

6.9 × 10−3

1449

????−−

−0.10

2.7 × 10 −4

6.0 × 10−3

Hydroxypropionylcarnitine

PC ae C38:4

7853

+−+−+++

0.04

9.0 × 10 −4

2.0 × 10−2

7638

+−+−++

0.03

4.7 × 10−3

3.1 × 10−2

Phosphatidylcholine acyl-alkyl C38:4

PC ae C40:3

7853

+++++++

0.04

1.6 × 10−3

3.0 × 10−2

7638

++++++

0.03

8.5 × 10−3

3.8 × 10−2

Phosphatidylcholine acyl-alkyl C40:3

PC ae C40:5

7853

+−+++++

0.04

1.9 × 10−3

3.1 × 10−2

7638

+−++++

0.03

1.9 × 10−2

1.0 × 10−1

Phosphatidylcholine acyl-alkyl C40:5

SM C20:2

7853

+−+−+++

0.03

2.4 × 10−3

3.5 × 10−2

7638

+−+−++

0.03

2.7 × 10−3

2.0 × 10−2

Sphingomyeline C20:2

C9

5262

+??−++ ?

0.04

2.9 × 10−3

3.8 × 10−2

5247

+??−++

0.04

1.1 × 10−2

7.5 × 10−2

Nonaylcarnitine

PC ae C40:4

7853

+0+++++

0.03

4.1 × 10−3

4.9 × 10−2

7638

+−++++

0.03

2.8 × 10−2

1.1 × 10−1

Phosphatidylcholine acyl-alkyl C40:4

PC aa C38:3

7852

−−−−+++

−0.03

7.0 × 10−3

7.5 × 10−2

7637

−−−−++

−0.02

3.5 × 10−2

1.3 × 10−1

Phosphatidylcholine diacyl C38:3

PC ae C36:1

7852

+−+−+++

0.03

7.4 × 10−3

7.5 × 10−2

7637

+−+−++

0.02

5.8 × 10−2

2.1 × 10−1

Phosphatidylcholine acyl-alkyl C36:1

PC aa C36:1

7850

−−−−+++

−0.03

9.3 × 10−3

8.3 × 10−2

7635

−−−−++

−0.03

4.0 × 10−3

3.0 × 10−2

Phosphatidylcholine diacyl C36:1

PC ae C40:6

7853

+−+−+++

0.03

9.5 × 10−3

8.3 × 10−2

7638

+−+−++

0.02

8.5 × 10−2

2.4 × 10−1

Phosphatidylcholine acyl-alkyl C40:6

SM (OH) C16:1

7047

+−+−?++

0.03

1.1 × 10−2

9.4 × 10−2

6832

+−+−?+

0.02

5.3 × 10−2

1.6 × 10−1

Hydroxysphingomyeline C16:1

C2

7853

−−+−−−+

−0.03

1.4 × 10−2

1.0 × 10−1

7638

−−+−−−

−0.03

1.5 × 10−2

8.3 × 10−2

Acetylcarnitine

PC ae C36:2

7853

++−−+++

0.03

1.4 × 10−2

1.0 × 10−1

7638

+−−−++

0.02

1.3 × 10−1

2.4 × 10−1

Phosphatidylcholine acyl-alkyl C36:2

PC ae C38:3

7852

+++−+++

0.03

1.7 × 10−2

1.1 × 10−1

7637

+++−++

0.02

3.6 × 10−2

1.3 × 10−1

Phosphatidylcholine acyl-alkyl C38:3

PC aa C42:0

7853

+++++++

0.03

2.0 × 10−2

1.3 × 10−1

7638

+++−++

0.02

8.9 × 10−2

2.4 × 10−1

Phosphatidylcholine diacyl C42:0

PC aa C32:0

7853

−−−−+++

−0.03

2.1 × 10−2

1.3 × 10−1

7638

−−−−++

−0.03

5.9 × 10−3

3.5 × 10−2

Phosphatidylcholine diacyl C32:0

PC aa C40:5

7849

−−−−+++

−0.03

2.2 × 10−2

1.3 × 10−1

7634

−−−−++

−0.03

1.7 × 10−2

8.3 × 10−2

Phosphatidylcholine diacyl C40:5

PC aa C38:1

836

?????++

0.08

2.6 × 10−2

1.5 × 10−1

643

?????+

0.05

1.7 × 10−1

2.4 × 10−1

Phosphatidylcholine diacyl C38:1

PC aa C36:2

7853

−−−−−++

−0.02

3.0 × 10−2

1.6 × 10−1

7638

−−−−−+

−0.03

1.0 × 10−2

4.9 × 10−2

Phosphatidylcholine diacyl C36:2

PC aa C34:1

7852

−−−−+++

−0.02

3.1 × 10−2

1.6 × 10−1

7637

−−−−++

−0.03

1.3 × 10−2

7.5 × 10−2

Phosphatidylcholine diacyl C34:1

PC ae C42:4

7853

+−+++++

0.02

3.5 × 10−2

1.8 × 10−1

7638

+−++++

0.01

2.1 × 10−1

2.5 × 10−1

Phosphatidylcholine acyl-alkyl C42:4

SM C26:0

5454

+??−+++

0.03

4.3 × 10−2

2.1 × 10−1

5246

+??−++

0.02

2.3 × 10−1

2.6 × 10−1

Sphingomyeline C26:0

  1. Abbreviations: n = number of participants, r = correlation coefficient, BMI = body mass index, FDR = false discovery rate.
  2. *Order of cohorts in direction column: KORA, NTR, EGCUT, TwinsUK, ERF, LLS, QIMR; Direction of effect represented by − (negative correlation) + (positive correlation) or ? (not included) for each study. Bold p-values: associations surpassing significance threshold (p-value < 1.1 × 10-3).
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