Figure 6
From: Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia
Proteomic investigation of the dynamic changes of proteins in FD and XEFP-treated rats, and discovery and verification of a new candidate target for the treatment of FD. (A) Volcano plot of dynamic changes of proteins in FD rats (model). (B) Biological process or molecular function of the proteins in model group with upregulated expression levels (p < 0.05) compared to the control. (C). Volcano plot of dynamic changes of proteins in FD rats after XEFP treatment. (D) Biological process or molecular function of the proteins of XEFP-treated FD rats with downregulated expression levels (p < 0.05) compared to model. (E) Proteomic quantitative analysis of the candidate target regulated by XEFP against FD in rats. (F) Western-blot verification of the new candidate target (striatin, STRN) for the treatment of FD. Blots were cropped from the same gel, but with different exposures (first striatin, then β-actin), and their full-length gels and blots are included in the Supporting Information file. XEFP-H, high-dosage XEFP. XEFP-M, medium-dosage XEFP. XEFP-L, low-dosage XEFP.
