Figure 6
From: Transformation of normal cells by aberrant activation of YAP via cMyc with TEAD
Mutant YAP is more potent than wild-type YAP in altering gene expression in NIH3T3 cells. (a) Scattered plots of global expression data in control NIH3T3 cells and cells expressing YAP or mtYAP. Global expression data from control NIH3T3 cells were compared with those expressing mtYAP (left panel) or wild-type YAP (right panel). Green and red dots indicate genes up- and down-regulated, respectively, more than two-fold due to expression of YAP or mtYAP. (b) Venn diagram showing the relationship among the top 786 genes whose expression levels were elevated by 1.65- and 2-fold from forced expression of YAP and mtYAP, respectively. (c) Significantly enriched GO terms of 502 genes that were commonly activated by both YAP and mtYAP. Terms directly linked to cell growth are indicated with in red font, while terms that are relatively related to cell growth are indicated with in green font.
