Figure 7
From: Transformation of normal cells by aberrant activation of YAP via cMyc with TEAD
Tumorigenic ability of MEFs by aberrant YAP activation alone. (a) Anchorage-independent growth of control MEFs and cells expressing LT and/or mtYAP. (b) Tumor formation ability of control MEFs and cells expressing LT and/or mtYAP. (c) Examination of cMyc expression levels in control MEFs and cells expressing LT and/or mtYAP under sparse (d2) and confluent conditions (d5). The expression level of cMyc gene in control NIH3T3 cells was arbitrarily set to one. Levels of significance were examined by one-way ANOVA. (d) Western blot analysis in control MEFs and cells expressing LT and/or mtYAP. cMYC protein was detected as multiple bands that may reflect posttranslational modifications.
