Table 2 Univariate and multivariate Cox regression analyses for progression-free survival.

From: Prognostic implications of soluble programmed death-ligand 1 and its dynamics during chemotherapy in unresectable pancreatic cancer

Variable

Univariate analysis

Multivariate analysis

mPFS (95% CI) (months)

P-value

HR

95% CI

P-value

Age, years

≥60

10.5 (7.0–14.0)

0.026

1

 

0.054

<60

5.9 (3.7–8.1)

 

1.954

0.989–3.862

 

Sex

Male

7.8 (5.0–10.6)

0.464

   

Female

5.9 (4.3–7.6)

    

Disease extent

LAPC

9.0 (3.6–14.3)

0.160

1

 

0.964

MPC

6.2 (4.5–7.9)

 

1.022

0.401–2.606

 

CA 19-9, U/mL

≥37.0

6.3 (4.6–8.1)

0.369

   

<37.0

7.8 (5.1–10.6)

    

Total bilirubin, mg/dL

>1.2

5.8 (5.1–6.6)

0.448

   

≤1.2

6.9 (5.3–8.6)

    

Albumin, g/dL

≥3.3

Not reached

0.428

   

<3.3

6.5 (4.9–8.0)

    

sPD-L1, ng/mL

≥4.6

4.1 (1.5–6.7)

0.021

2.077

0.915–4.712

0.080

<4.6

7.8 (5.3–10.3)

 

1

  

NLR

≥1.83

6.2 (4.8–7.6)

0.008

3.141

0.950–10.391

0.061

<1.83

Not reached

 

1

  

PLR

≥109.6

6.2 (5.2–7.3)

0.011

1.060

0.392–2.866

0.908

<109.6

10.5 (0.1–22.3)

 

1

  
  1. Abbreviations: LAPC = locally advanced pancreatic cancer; MPC = metastatic pancreatic cancer; CA 19-9 = cancer antigen 19-9; sPD-L1 = soluble programmed death-ligand 1; NLR = neutrophil-to-lymphocyte ratio; PLR = platelet-to-lymphocyte ratio; mPFS = median progression-free survival; CI = confidence interval; and HR = hazard ratio.
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