Table 3 Univariate and multivariate Cox regression analyses for overall survival.

From: Prognostic implications of soluble programmed death-ligand 1 and its dynamics during chemotherapy in unresectable pancreatic cancer

Variable

Univariate analysis

Multivariate analysis

mOS (95% CI) (months)

P-value

HR

95% CI

P-value

Age, years

≥60

17.1 (0.3–33.9)

0.029

1

 

0.087

<60

10.3 (8.8–11.8)

 

1.878

0.913–3.865

 

Sex

Male

12.6 (8.2–17.0)

0.514

   

Female

10.3 (8.3–12.3)

    

Disease extent

LAPC

16.8 (16.2–17.4)

0.051

1

 

0.465

MPC

10.0 (9.0–11.0)

 

1.395

0.572–3.402

 

CA 19-9, U/mL

≥37.0

10.0 (8.8–11.2)

0.587

   

<37.0

16.7 (10.2–23.2)

    

Total bilirubin, mg/dL

>1.2

9.7 (6.6–12.8)

0.255

   

≤1.2

11.4 (8.2–14.6)

    

Albumin, g/dL

≥3.3

10.6 (8.7–12.5)

0.802

   

<3.3

9.9 (0.1–25.7)

    

sPD-L1, ng/mL

≥4.6

8.0 (6.6–9.4)

0.003

2.796

1.221–6.400

0.015

<4.6

12.6 (9.1–16.1)

 

1

  

NLR

≥1.83

10.0 (8.8–11.2)

0.006

4.823

1.554–14.971

0.006

<1.83

Not reached

 

1

  

PLR

≥109.6

10.3 (8.4–12.2)

0.129

1.855

0.729–4.720

0.195

<109.6

17.1 (3.7–30.5)

 

1

  
  1. Abbreviations: LAPC = locally advanced pancreatic cancer; MPC = metastatic pancreatic cancer; CA 19-9 = cancer antigen 19-9; sPD-L1 = soluble programmed death-ligand 1; NLR = neutrophil-to-lymphocyte ratio; PLR = platelet-to-lymphocyte ratio; mOS = median overall survival; CI = confidence interval; and HR = hazard ratio.
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