Figure 2

Behavior of each species during conditions of (a) no costimulation, (b) 4-1BB mono-costimulation, (c) OX40 mono-costimulation, and (d) dual costimulation. Low, medium, and high activity of molecular species are represented by Levels 0, 1, and 2, respectively. The solid line and shaded region represent, respectively, the mean and standard deviation of 100 simulations.