Table 3 Diagnostic values of serum autoantibody biomarkers and AFP.

From: Serum anti-EIF3A autoantibody as a potential diagnostic marker for hepatocellular carcinoma

Biomarkers

AUCa

Sensitivityb (%)

Specificityc (%)

PPVd (%)

NPVe (%)

ACCf (%)

AFP

0.77

53.9

100.0

100.0

64.4

74.9

α-SF3B1 autoAb

0.82

73.5

90.6

90.4

74.0

81.3

α-EIF3A autoAb

0.81

79.4

83.5

85.3

77.2

81.3

α-EIF3A + AFP

0.90

88.2

83.5

86.5

85.5

86.1

α-EIF3A + α-SF3B1

0.91

92.2

74.1

81.0

88.7

84.0

α-EIF3A + α-SF3B1 + AFP

0.94

94.1

74.1

81.4

91.3

85.0

  1. aAUC: Area under curve.
  2. bSensitivity, True positive rate, probability of detection = Σ True positive/Σ Condition positive.
  3. cSpecificity, Selectivity, True negative rate = Σ True negative/Σ Condition negative.
  4. dPPV: Positive predictive value, Precision = Σ True positive/Σ Predicted condition positive.
  5. eNPV: Negative predictive value = Σ True negative/Σ Predicted condition negative.
  6. fACC: Accuracy = Σ True positive + Σ True negative/Σ Total population.
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