Table 3 Relationship between studied gene polymorphisms and neonatal anthropometric bioimpedance characteristics.

From: MC4R and ENPP1 gene polymorphisms and their implication in maternal and neonatal risk for obesity

Factors

Birth weight (kg)

MUAC (cm)

TST (cm)

Mean ± SD

p+

Median[Q1; Q3]

p+

Median[Q1; Q3]

p+

BMI initial (kg/m 2 )

<25

3.33 ± 0.45

0.094

10.5[10.0; 11.3]

0.075

2.8[2.3; 3.4]

0.912

≥25

3.46 ± 0.45

11.0[10.5; 11.5]

2.9[2.4; 3.2]

GWG status

Insufficient

3.11 ± 0.49

<0.001

10.3[9.7; 10.8]

0.005

2.3[2.0; 2.8]

<0.001

Normal

3.28 ± 0.43

10.5[10.2; 11.4]

2.8[2.4; 3.5]

Excessive

3.46 ± 0.42

11.0[10.5; 11.5]

2.3[2.0; 2.8]

MC4R rs17782313 Maternal SNP

TT

3.37 ± 0.43

0.892

11.0[10.3; 11.5]

0.149

2.9[2.3; 3.4]

0.519

CT + CC

3.36 ± 0.48

10.5[10.0; 11.5]

2.8[2.4; 3.5]

ENPP1 rs1044498 Maternal SNP

AA

3.35 ± 0.43

0.333

10.5[10.0; 11.3]

0.085

2.8[2.3; 3.2]

0.208

AC + CC

3.42 ± 0.49

11.0[10.3; 11.5]

3.0 [2.4; 3.4]

MC4R rs17782313 Neonates SNP

TT

3.40 ± 0.45

0.250

11.0[10.3; 11.5]

0.035

2.8[2.3; 3.2]

0.346

CT + CC

3.32 ± 0.48

10.5[10.0; 11.2]

3.0 [2.4; 3.4]

ENPP1 rs1044498 Neonates SNP

AA

3.35 ± 0.42

0.538

10.5[10.0; 11.4]

0.105

2.8[2.3; 3.2]

0.123

AC + CC

3.40 ± 0.45

11.0[10.3; 11.5]

3.0 [2.3; 3.5]

  1. Legend: SD = standard deviation; Q1 = first quartile; Q3 = third quartile; +p-values obtained from Student-t test for independent samples, ANOVA test or nonparametric test (as Mann-Whitney or Kruskal-Wallis).
  2. BMI: Body mass index, BW: birth weight, MUAC: Middle upper arm circumference, SD: standard deviation, TST: Tricipital skinfold thickness.
  3. ENPP1 rs1044498 A > C: nucleotide pyrophosphatase/phosphodiesterase gene polymorphisms (AA = reference category); AA – homozygous for A allele; AC – heterozygous; CC - homozygous for C allele;
  4. MC4R rs17782313 T > C: melanocortin- 4 receptor gene polymorphisms (TT = reference category); CC - homozygous for C allele; CT - heterozygous; TT- homozygous for T allele.