Table 4 Survival analysis of factors associated with serum PlGF and EGF levels.

From: Serum PlGF and EGF are independent prognostic markers in non-metastatic colorectal cancer

v

Training cohort

Validation cohort

Log-rank δ

HR (95% CI)ε

p ζ

Log-rank δ

HR (95% CI)ε

p ζ

PlGF

OS

0.003*

1.056 (1.001–1.114)

0.046

0.021*

1.093 (1.003–1.191)

0.001

DFS

0.035*

1.052 (1.005–1.107)

0.029

<0.001*

1.091 (1.033–1.153)

0.009

EGF

OS

0.162*

 

0.201

0.400*

 

0.453

DFS

0.027

0.998 (0.996–1.0)

0.045

0.065*

0.998 (0.996–1.000)

0.018

VEGF

OS

0.328*

 

0.087

0.360*

 

0.368

DFS

0.350*

 

0.153

0.344*

 

0.376

Validation cohort

OS

0.745*

 

0.978

0.015*

 

0.140

DFS

0.699*

 

0.793

0.056*

 

0.413

PDGF-A

OS

0.807*

 

0.370

0.101*

 

0.062

DFS

0.286*

 

0.575

0.278*

 

0.116

PDGF-B

OS

0.647*

 

0.808

0.534*

 

0.183

DFS

0.728*

 

0.993

0.987*

 

0.375

IL-8

OS

0.393*

 

0.671

0.022*

 

0.564

DFS

0.838*

 

0.652

0.064*

 

0.617

bFGF

OS

0.190*

 

0.399

0.855*

 

0.470

DFS

0.691*

 

0.948

0.564*

 

0.824

Sex

OS

0.386

 

0.239

0.692

 

0.932

DFS

0.136

 

0.064

0.481

 

0.811

Age >70

OS

0.009

 

0.365

<0.001

4.3 (2.2–8.3)

<0.001

DFS

0.018

 

0.628

<0.001

2.2 (1.3–3.8)

0.004

SOD

OS

0.985

 

—

0.752

 

—

DFS

0.311

 

—

0.546

 

—

neoadj. Tx

OS

0.759

 

—

0.510

 

—

DFS

0.155

 

—

0.046

 

0.140

pT

OS

0.638

 

—

0.001

 

—

DFS

0.087

 

—

0.004

 

—

pN

OS

0.064

 

—

0.015

 

—

DFS

0.009

 

—

0.031

 

—

UICC stage

OS

0.064

2.2 (1.1–4.3)

0.020

0.013

1.7 (0.9–3.9)

0.086

DFS

0.009

2.8 (1.5–5.0)

0.001

0.028

1.9 (1.1–3.4)

0.022

Grade

OS

0.188

 

—

0.506

 

—

DFS

0.338

 

—

0.677

 

—

  1. δP-values using the univariate log-rank test, median was used as a cutoff for PlGF and EGF; εHazard ratio (HR) and 95% confidence interval (CI) for the multivariate Cox regression model; ζp-values of the multivariate Cox regressions model; *75%-percentile was used as a cutoff.
  2. Abbreviations: BMI, body mass index; UICC, Union Internationale Contre le Cancer; PlGF, Phosphatidylinositol-glycan biosynthesis class F protein/placental growth factor; EGF, epidermal growth factor; SOD, site of disease; OS, overall survival; PFS, progression free survival.
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