Table 1 Microglia-related genes expressed in both MG and D-MG groups.

From: Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells

Gene Name

MG-1

MG-2

MG-3

D-MG-1

D-MG-2

D-MG-3

Ave (MG)

Ave (D-MG)

DMG/MG

LOG2 (DMG/MG)

SPI1

0.034

0.000

0.000

0.082

0.039

0.095

0.011

0.072

6.411

2.68

ITGAM

0.010

0.010

0.028

0.109

0.069

0.042

0.016

0.073

4.634

2.21

SIGLEC11

0.030

0.000

0.000

0.109

0.017

0.000

0.010

0.042

4.223

2.08

IL34

0.197

0.145

0.207

0.839

0.543

0.592

0.183

0.658

3.597

1.85

ENTPD1

0.401

0.346

0.404

1.300

1.278

1.235

0.384

1.271

3.310

1.73

GPR34

0.049

0.024

0.103

0.119

0.057

0.173

0.059

0.116

1.985

0.99

CX3CR1

0.039

0.025

0.018

0.063

0.045

0.055

0.027

0.054

1.979

0.98

TLR4

0.082

0.040

0.057

0.089

0.095

0.115

0.060

0.100

1.675

0.74

CD163

0.068

0.066

0.047

0.110

0.065

0.064

0.060

0.080

1.318

0.40

CD14

0.497

0.281

0.439

0.668

0.333

0.406

0.406

0.469

1.156

0.21

CSF1R

0.235

0.321

0.329

0.157

0.313

0.481

0.295

0.317

1.075

0.10

RUNX1

1.054

1.122

1.093

0.885

1.228

1.354

1.090

1.156

1.061

0.08

CNR1 (CB1)

3.040

2.760

3.118

2.950

2.483

2.992

2.973

2.808

0.945

−0.08

AIF1

0.137

0.139

0.128

0.142

0.123

0.079

0.135

0.115

0.853

−0.23

CTSD

181.030

141.431

181.199

126.489

165.501

133.915

167.887

141.968

0.846

−0.24

GAS6-AS1

0.106

0.310

0.148

0.192

0.122

0.075

0.188

0.130

0.692

−0.53

ITM2B

187.148

165.841

188.395

98.238

130.503

126.546

180.461

118.429

0.656

−0.61

IRF8

0.249

0.191

0.248

0.129

0.082

0.150

0.229

0.121

0.527

−0.93

GAS6

23.550

18.779

22.989

10.804

11.318

10.370

21.772

10.831

0.497

−1.01

SELPLG

1.070

0.597

0.926

0.227

0.511

0.503

0.864

0.414

0.479

−1.06

PTPRC

0.013

0.025

0.009

0.000

0.022

0.000

0.016

0.007

0.476

−1.07

MERTK

10.754

12.517

10.041

5.241

4.409

5.152

11.104

4.934

0.444

−1.17

ITGB5

26.159

21.157

26.867

9.465

8.988

12.065

24.728

10.172

0.411

−1.28

TMEM119

0.455

0.154

0.636

0.170

0.162

0.173

0.415

0.168

0.406

−1.30

CD200R1

0.296

0.231

0.221

0.072

0.160

0.056

0.249

0.096

0.385

−1.38

CD74 (HLA-DR)

20.273

16.700

19.614

5.158

6.417

8.057

18.862

6.544

0.347

−1.53

TLR2

0.250

0.258

0.214

0.101

0.016

0.118

0.241

0.078

0.326

−1.62

CD274

0.128

0.113

0.233

0.016

0.045

0.091

0.158

0.050

0.318

−1.65

CD68

21.240

19.006

23.817

6.311

7.493

6.363

21.354

6.722

0.315

−1.67

CST3

140.183

95.749

136.805

26.568

30.377

30.928

124.246

29.291

0.236

−2.08

PROS1

14.510

14.664

14.544

2.775

3.319

3.709

14.573

3.267

0.224

−2.16

SIRPA (CD172a)

5.045

4.001

4.854

0.885

0.880

1.207

4.634

0.991

0.214

−2.23

TLR3

0.295

0.243

0.282

0.057

0.018

0.088

0.274

0.054

0.198

−2.34

CSF1

14.002

12.015

13.027

2.243

2.451

2.905

13.015

2.533

0.195

−2.36

RGS10

27.176

23.513

24.422

3.360

3.991

5.138

25.037

4.163

0.166

−2.59

OLFML3

238.303

208.748

232.245

29.021

26.068

31.671

226.432

28.920

0.128

−2.97

TYROBP

2.639

2.656

2.124

0.194

0.371

0.226

2.473

0.264

0.107

−3.23

P2RY11

0.335

0.537

0.033

2.208

1.441

1.384

0.302

1.678

5.557

2.47

P2RY14

0.000

0.033

0.023

0.061

0.058

0.047

0.019

0.055

2.967

1.57

P2RY1

1.019

1.396

1.446

1.552

1.339

1.395

1.287

1.429

1.110

0.15

P2RY4

0.115

0.169

0.242

0.140

0.267

0.081

0.175

0.163

0.929

−0.11

P2RY2

0.296

0.238

0.333

0.116

0.282

0.276

0.289

0.225

0.777

−0.36

P2RY6

1.319

1.129

1.492

0.504

0.446

0.607

1.313

0.519

0.395

−1.34

  1. The FPKM (fragments per kilobase per million reads) normalized values for these genes are listed for all samples. The numbers in the last column are the Log2 values of ratios of D-MG to MG. Negative values indicate that the genes are present in higher amounts in MG group, while positive values indicate that the genes are present in higher amounts in D-MG group.
  2. The genes were separated into different groups based on: upregulated in DMGs (>+0.50 fold); similar expression (−0.49 to +0.49 fold); upregulated in MGs (−0.50 to −2.00 fold); highly upregulated in MGs (<−2.00 fold), and P2RY receptors.
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