Table 2 Microglia immunophenotype suggests differences in immune vigilance for D-MG and MG groups.

From: Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells

Gene Name

MG-1

MG-2

MG-3

D-MG-1

D-MG-2

D-MG-3

Ave (MG)

Ave (D-MG)

DMG/MG

LOG2 (DMG/MG)

Interferon pathway

STAT1

18.863

18.003

17.906

12.591

16.296

13.932

18.258

14.273

0.782

−0.36

STAT4

0.321

0.448

0.235

0.242

0.177

0.259

0.335

0.226

0.675

−0.57

OAS1

0.238

0.232

0.199

0.087

0.055

0.101

0.223

0.081

0.362

−1.47

IFIT2

0.974

0.912

0.756

0.164

0.172

0.229

0.881

0.189

0.214

−2.22

PLSCR1

12.662

11.825

11.660

1.949

1.710

2.083

12.049

1.914

0.159

−2.65

IFITM3

465.310

367.927

441.155

53.291

57.131

73.014

424.797

61.145

0.144

−2.80

SIGLEC family

SIGLEC1

0.028

0.021

0.020

0.111

0.114

0.129

0.023

0.118

5.178

2.37

SIGLEC11

0.030

0.000

0.000

0.109

0.017

0.000

0.010

0.042

4.223

2.08

SIGLEC14

0.000

0.022

0.000

0.000

0.052

0.032

0.007

0.028

3.817

1.93

SIGLEC5

0.000

0.018

0.000

0.023

0.043

0.000

0.006

0.022

3.615

1.85

SIGLEC16

0.029

0.029

0.082

0.143

0.170

0.166

0.047

0.160

3.415

1.77

SIGLEC15

0.094

0.092

0.088

0.114

0.073

0.044

0.091

0.077

0.845

−0.24

SIGLEC10

0.125

0.190

0.078

0.135

0.081

0.039

0.131

0.085

0.649

−0.62

SIGLEC6

0.197

0.600

1.104

0.133

0.203

0.279

0.634

0.205

0.324

−1.63

SIGLEC9

0.023

0.046

0.033

0.028

0.000

0.000

0.034

0.009

0.279

−1.84

Activating members

TREM1

0.015

0.015

0.151

0.169

0.412

0.000

0.061

0.194

3.195

1.68

CD300LB

0.062

0.020

0.115

0.200

0.119

0.058

0.066

0.126

1.916

0.94

CD300LF

0.023

0.022

0.000

0.028

0.000

0.032

0.015

0.020

1.329

0.41

Inhibitory members

SIGLEC5

0.000

0.018

0.000

0.023

0.043

0.000

0.006

0.022

3.615

1.85

CD200

11.187

13.126

11.137

18.303

20.706

20.599

11.817

19.869

1.681

0.75

CD300A

0.974

0.829

0.908

0.728

1.012

0.529

0.904

0.756

0.837

−0.26

CD47

12.758

15.348

12.051

9.623

9.966

9.872

13.386

9.820

0.734

−0.45

CD200R1

0.296

0.231

0.221

0.072

0.160

0.056

0.249

0.096

0.385

−1.38

SIRPA

5.045

4.001

4.854

0.885

0.880

1.207

4.634

0.991

0.214

−2.23

CD22

1.090

1.023

0.902

0.157

0.083

0.121

1.005

0.120

0.120

−3.06

  1. The FPKM (fragments per kilobase per million reads) normalized values for these genes are listed for all samples. The numbers in the last column are the Log2 values of ratios of D-MG to MG. Negative values indicate that the genes are present in higher amounts in MG group, while positive values indicate that the genes are present in higher amounts in D-MG group.
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