Figure 2 | Scientific Reports

Figure 2

From: Reversibility of Age-related Oxidized Free NADH Redox States in Alzheimer’s Disease Neurons by Imposed External Cys/CySS Redox Shifts

Figure 2

Mitochondrial NADH shifts toward more bound NADH with oxidative states and toward more free form in response to the imposed external reductive treatment (female neurons). Each dot or cross point represents one neuron, the average of mitochondrial regions (ROIs) from a single NTg or 3xTg-AD neuron (n = 10 neurons/age/genotype/redox state = 180 points). The dashed ellipses are manual groupings by imposed redox state. Note that mitochondrial free/bound NADH re-distributes in response to the manipulated external Cys/CySS redox states from reductive (−150 mV) to oxidative (0 mV) in both genotypes and three ages are shown by the colored arrow (ANOVA for G, F(2, 179) = 547, p < 0.001; for S, F(2, 179) = 356, p < 0.001).

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