Figure 3 | Scientific Reports

Figure 3

From: Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation

Figure 3

Covalent binding modes in the SB1495-bound and SB1494-bound PPARγ LBD structures. (A) Ribbon model of SB1495-bound PPARγ LBD (bright orange) in complex with the SRC-1 peptide (grey). SB1495, displayed as a green ball-and-stick model, occupies the LBP of PPARγ. The mFo-DFc electron density omit map contoured at 2.5σ for SB1495 is represented as a light teal-colored mesh. The right panel shows a magnified image of interactions between PPARγ Cys285 and SB1495. (B) Ribbon model of SB1494-bound PPARγ LBD (pale cyan) in complex with the SRC-1 peptide (grey). SB1494, displayed as a cyan ball-and-stick model, is represented in the same way as SB1495 (A).

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