Figure 3
From: Gene-environment interaction counterbalances social impairment in mouse models of autism
Increased seizure susceptibility in Cntnap2 KO and VPA-exposed mice is further enhanced by the interaction of these factors. (a) Current vs. convulsion rate plot. (b) Current that induced convulsions in 50% of the animals was defined as the CC50. Summary of the mean and S.E.M of the CC50. WT × Veh, n = 10; KO × Veh, n = 6; WT × VPA, n = 6; KO × VPA, n = 7. Abbreviations: WT, Cntnap2 WT mice; KO, Cntnap2 KO mice; VPA, treatment with valproic acid (300 mpk) at E10.5; Veh, treatment with phosphate-buffered saline at E10.5.
