Figure 5
From: Gene-environment interaction counterbalances social impairment in mouse models of autism
mIPSCs are not affected by Cntnap2 KO, prenatal VPA exposure, or the interaction of these factors. Whole-cell patch-clamp recordings in neurons in layer 2/3 of the mPFC. (a) Representative mIPSC traces. (b) mIPSC amplitudes. (c) mIPSC frequencies. Two-way ANOVA followed by Fisher’s LSD test was performed to determine significant between-group differences. WT × Veh, n = 9; KO × Veh, n = 9; WT × VPA, n = 10; KO × VPA, n = 11. In all bar graphs, data are the mean ± S.E.M. Abbreviations: WT, Cntnap2 WT mice; KO, Cntnap2 KO mice; VPA, treatment with valproic acid (300 mpk) at E10.5; Veh, treatment with phosphate-buffered saline at E10.5.
