Figure 4 | Scientific Reports

Figure 4

From: Integrated genomic epidemiology and phenotypic profiling of Clostridium difficile across intra-hospital and community populations in Colombia

Figure 4The alternative text for this image may have been generated using AI.

Genomic and phenotypic characterization of the antimicrobial resistance capacity of Colombian Clostridium difficile clinical isolates. (a) Frequency of antimicrobial resistance molecular markers (AMR-MMs) identification in reads obtained from whole genome sequencing of the clinical isolates. (b) MIC50 against 10 antimicrobial agents MET, metronidazole; VAN, vancomycin; TET, tetracycline; ERY, erythromycin; RIF, rifampicin; AMP, ampicillin; PEN, penicillin; FUS.AC, fusidic acid; CLI, clindamycin; MOX, moxifloxacin. The red dotted line represents the average concentration evaluated for each antimicrobial agent. MLS: Macrolide-lincosamide-streptogramin. The graphical representation of results was developed in Plotly server66. (c) Comparison of the detection frequency of the AMR-MMs with the MIC50 results. We identified as an association those comparisons that had a p < 0.05 after a Chi2 test. *Concentration range for MET, RIF and MOX was from 0.39 to 13; for AC.FUS, AMP and PEN was from 0.78 to 25; for VAN and TET was from 4.69 to 150; for ERY was from 1.17 to 38; and for CLI was from 0.15 to 5.

Back to article page