Figure 3

Differential protein expression in lesional (L) and non-lesional (NL) skin and affected biological processes. Heatmap of relative expression for proteins differentially expressed in L and NL skin (a, left column) and the relative expression of these proteins NL and L skin (middle column) and L and healthy (H) skin (right column) (a). Biological processes for which proteins were differentially expressed in L and NL are listed. The top ten processes depicted to be affected in response to stimulus (b left, filled orange circles) and development (b right, filled blue circles). False detection rate (FDR) values are indicated with unfilled red circles around the filled circles for the various biological processes. The size of each circle is proportional to FDR values (unfilled red circles) or to the number of proteins (filled circles) (b). Proteins differentially expressed in L and NL but not in H and L are listed (c). Proteins for which the changes in NL and L compared to H are in different directions (increased vs. decreased and vice versa) are listed (d). Proteins that exhibited altered expression only in lesions (potentially trigger proteins) with known (e) and novel (f) association with psoriasis are listed. (*Significant difference in relative protein expression at least by two-fold in L and NL comparison).