Figure 4 | Scientific Reports

Figure 4

From: Comprehensive Proteomic Analysis Reveals Intermediate Stage of Non-Lesional Psoriatic Skin and Points out the Importance of Proteins Outside this Trend

Figure 4

Differentially expressed proteins in non-lesional (NL) and healthy (H) skin. Proteins with expression that differs by at least 2-fold in non-lesional skin and healthy skin are listed (a). UGDH protein expression is similarly increased in NL and lesional psoriatic skin, compared to H controls. The highest difference in expression for NL and H was seen with immunohistochemical characterization of UGDH (n = 10), which indicated similar patterns of distribution in the three sample types. The strongest staining was observed in basal keratinocytes, and weaker staining was observed in the upper parts of the epidermis. Higher intensity staining UGDH was observed in non-lesional and lesional skin compared to healthy skin (b). A higher magnification of the epidermis is provided (c). (In merged figures, DAPI nuclear staining and UGDH are shown in blue and red, respectively; *: indicates statistical significance, ¥: indicates proteins with known association with psoriasis).

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