Figure 6 | Scientific Reports

Figure 6

From: Detection and targeting insulin growth factor receptor type 2 (IGF2R) in osteosarcoma PDX in mouse models and in canine osteosarcoma tumors

Figure 6

Radioimmunotherapy of OS tumor-bearing SCID mice: (a) 143B tumors; (b) OS-17 tumors. The mice were given IP either 80 μCi 177Lu-2G11, or 80 μCi 177Lu-MOPC-21, or unlabeled (cold) 2G11, or was left untreated. A group of 143B tumor bearing mice were also given 80 μCi 213Bi-2G11. Administration of 177Lu-2G11 significantly (P < 0.05, denoted with *) slowed down the growth of both 143B (a) and OS-17 tumors (b) in comparison with the untreated tumors and “cold” 2G11. The treatment effect was IGF2R-specific as the control mAb MOPC-21 radiolabeled with the same activity of 177Lu, had significantly less effect on the tumor growth rate (P = 0.06).

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