Table 1 Summary of breeding outcomes at birth.

From: Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2rI1565A) results in partial lethality, overgrowth and intestinal adenoma progression

Igf2rI1565A allele transmission

Cross

Genotypes

Observed

Expected

 

Maternal

Igf2r+m/I565A ♀ × Igf2r+m/+p

Igf2r +m/+p

39

34.5

*P = NS

(11 litters, 5 pairs)

Igf2r I565A/+ p

30

34.5

Paternal

Igf2r+m/+p ♀ × Igf2r+m/I565A

Igf2r +m/+p

25

27

*P = NS

(10 litters, 3 pairs)

Igf2r + m/I565A

29

27

Homozygote

Igf2r+m/I565A ♀ × Igf2r+m/I565A

Igf2r +m/+p

25

14.75

*P = 0.0006

X2 = 14.97

Igf2r + m/I565A or Igf2r I565A/+ p

30

29.5

(9 litters, 3 pairs)

Igf2r I565A/I565A

4

14.75

  1. *X2 and one-way ANOVA, Kruskal-Wallis, with Dunns multiple comparison post-test.