Table 3 Replication Results for Significant and Suggestive Loci for the ABI in Stratified Subgroup Analyses.

From: Variants Associated with the Ankle Brachial Index Differ by Hispanic/Latino Ethnic Group: a genome-wide association study in the Hispanic Community Health Study/Study of Latinos

HCHS/SOL group

Index SNP

Chr

Allele A

Allele B

HCHS/SOL

MESA Hispanic

MESA AA

MESA EA

Beta

p-value

Beta

p-value

Beta

p-value

Beta

p-value

Dominican

rs6750426

2

G

A

0.031

7.39E-08

−0.006

5.58E-01

−0.019

6.79E-01

−0.023

7.93E-01

Puerto Rican

rs4466200

5

G

A

0.024

3.40E-09

0.016

3.34E-01

0.074

2.16E-02

−0.037

8.81E-01

Puerto Rican

rs7755533

6

G

A

0.022

9.28E-08

0.014

3.73E-01

0.024

2.82E-01

0.043

1.02E-01

Central American

rs6631478

X

T

C

−0.024

7.02E-08

−0.118

2.22E-04

−0.012

3.52E-01

0.013

6.43E-01

Caribbean

rs3133941

8

A

G

−0.018

1.78E-08

−0.032

2.50E-01

−0.04

1.27E-01

−0.001

4.94E-01

  1. *Allele A is the effect allele. All variants were imputed, and all were common (MAF range 0.11–0.48 across all variants and all ethnic groups) in MESA. MESA replication sample sizes were n = 1,447 (Hispanic), n = 1,613 African American (AA), and n = 2,527 European American (EA). Rs113916643 was not available in MESA and is omitted from this table.
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