Figure 3

The accuracy of the four prediction methods for (a) negative and (b) positive epistatic interactions. The outer panels show precision (fraction of predictions that are confirmed by the experimental data) vs. recall (fraction of experimentally observed interactions that are predicted correctly), while the insets show a detail of the receiver operator characteristic (ROC) curve, tracing the dependence of recall on the false positive prediction rate (FPR = 1 – specificity, the fraction of predicted epistasis cases that are not confirmed by the experimental data).