Table 1 Effect of variation in experimental parameters on the physicochemical properties of the nanoemulsions prepared by self-emulsification.

From: Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs

Formulation variables

NEs characterization*

Solutol®HS15 conc. (mg/mL)

Miglyol®812/Tween®80 ratio (w/w)

Oil/aq. phase ratio (v/v)

Size (nm)

2.5

1:1

1:2

138 ± 3

5

138 ± 2

15

149 ± 3

25

140 ± 1

2.5

1:1

1:2

138 ± 3

1.5 :1

147 ± 3

2 :1

164 ± 1

3.5 :1

159 ± 3

2.5

1:1

1:3

139 ± 2

1:4

144 ± 1

1:5

152 ± 3

1:8

138 ± 3

  1. *Polydispersity index was 0.2 for all formulations except 3.5:1 Miglyol®812/Tween®80 ratio which was 0.3.