Figure 8
From: Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis
Proposed model for the accumulation of lipid droplets in astrocytes. Under normal conditions, circulating glucose is taken up by astrocytes, converted to lactate and shuttled to neurons for ATP production. Increasing evidences indicate that elevated ROS and mitochondrial defects in neurons trigger lipid droplet formation in astrocytes. In this scenario, our lipidomic data demonstrate that lipid accumulating in the spinal cord are mainly consisted of cholesteryl ester species. Scheme adapted from Liu et al., 2017 and Ioannou et al.48,50.
