Figure 8
From: LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1
Schematic map of SAMD12-AS1 regulating cell proliferation and apoptosis. HBV-encoded HBx promotes the transcription of SAMD12-AS1. SAMD12-AS1 interacts with NPM1 to prevent its association with HDM2. Consequently, HDM2 binds to p53 and enhances p53 ubiquitination and degradation, which in turn promotes cell proliferation and inhibits apoptosis.
