Figure 1 | Scientific Reports

Figure 1

From: Citrullination facilitates cross-reactivity of rheumatoid factor with non-IgG1 Fc epitopes in rheumatoid arthritis

Figure 1

Regions of homology between predicted RF epitopes in IgG1 Fc and fibrinogen are targets for citrullination. (a) Three dimensional structures of regions of homology between IgG1 Fc and fibrinogen generated using PyMOL software. Sequences were scanned for regions of alignment using ExPASy SIM and LALIGN. Numerals indicate amino acid starting position and bold characters indicate amino acid substitutions. Characters highlighted in red identify arginine residues susceptible to citrullination. (b) Structures of regions of homology identified in (a) after modification of arginine residues to citrulline using PyTMs plugin. (c) Structure of the Fc region of IgG1 with the three predicted RF epitopes highlighted: KPREE (green), KSRW (cyan), and DELTK (magenta).

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