Table 2 Estimated coefficients (uncorrected and corrected for optimism) of pre-treatment and ∆image biomarkers models fitted to the entire dataset.

Pre-treatment reference model

intercept

−3.794

−3.385*

Xer_baseline

2.531

2.280*

12.56 (3.39–46.54)

<0.001

Parotid gland dose

0.099

0.089*

1.1 (1.03–1.18)

0.005

∆feature model 1

intercept

−3.139

−2.515

Xer_baseline

2.533

2.074

12.59 (3.13–50.73)

<0.001

∆PG-surface_w3 (cm²)

−0.568

−0.465

0.57 (0.41–0.79)

0.001

∆feature model 2

intercept

−4.515

−3.305

Xer_baseline

2.591

1.936

13.35 (3.13–56.95)

<0.001

Parotid gland dose

0.072

0.054

1.07 (0.77–1.51)

0.074

∆PG-surface_w3 (cm²)

−0.481

−0.360

0.62 (0.57–0.67)

0.005