Figure 1
From: Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice
In vitro characterization of two PFKFB3 inhibitors. (a) Incubation of A549 cells with AZ67 (1 h) dose-dependently decreases F2,6BP concentration. (b) Incubation of A549 cells with PFK158 (1 h) dose-dependently decreases F2,6BP concentration. (c) Incubation of human recombinant PFKFB3 with AZ67 dose-dependently inhibits PFKFB3 kinase activity. (d) Incubation of human recombinant PFKFB3 with PFK158 does not inhibit PFKFB3 kinase activity. See also Supplementary Data 1.
