Table 2 Drug release, capsule disintegration, unfolding (pH 1.2) and Young’s modulus tests results.
From: Development of Gabapentin Expandable Gastroretentive Controlled Drug Delivery System
Formula | Cumulative drug release % (6 hours) | Capsule disintegration time (minutes) | Unfolding test | Young’s modulus (N/mm2) |
|---|---|---|---|---|
F.A | 81.8 | 2.1 | Fail | 0.0117 |
F.B | 73.1 | 2.5 | Fail | 0.0079 |
F.C | 49.8 | 3.6 | N/A*a | N/A*a |
F.D | 60.0 | 2.4 | N/A*a | N/A*a |
F.E | 91.2 | 3 | Pass*b | 0.0142 |
F.F | 78.2 | 3.4 | Pass | 0.0067 |
F.G | 77.5 | 2.8 | Pass | Fail*c |
F.H | 84.9 | 3.7 | Fail | 0.0174 |
F.I | 78.7 | 3.6 | Fail | 0.0086 |
F.J | 89.5 | 4 | Pass | 0.0258 |
F.K | 79.4 | 2.7 | Fail | 0.0115 |
F.L | 82.8 | 3.6 | N/A*a | N/A*a |
F.M | 91.3 | 2.4 | Pass | 0.0133 |
F.N | 72.0 | 3.8 | N/A*a | N/A*a |
F.O | 81.4 | 3.4 | N/A*a | N/A*a |
F.P | 94.5 | 3 | Fail | 0.0164 |
F.Q | 100 | 3.7 | Pass | 0.0258 |
F.R | 94.6 | 2.8 | N/A*a | N/A*a |
F.S | 98.6 | 2 | N/A*a | N/A*a |
