Figure 2

Relationships between topology measures and gene essentiality in PPI networks. (A) The absolute value of the Pearson correlation coefficient (|R|) between the fraction of EGs and topology measures. Proteins were sorted by a given topology measure and divided into bins each containing 2% of the population. (B) |R| between centrality measures and clustering measures. (C) Principle component (PC) analysis of topology measures on EGs in the yeast consolidated network. The variance explained by each component is given in parentheses. (D) Pruning analysis. The change in excess clustering (ΔC) was monitored while proteins were progressively removed in decreasing order of a given topology measure, or randomly (gray line; area, 3σ). ΔC is the difference between the observed C and the mean C of randomized networks. (E) Summary of pruning analyses in different networks. The decrease of ΔC was quantified by the area under the random pruning curve.