Table 2 Two sample MR of causal association of psychiatric disorders on female reproduction traits of interest.

	Method	#Instruments	DF	AFB		AFS		AMC		AMP		NLB
	Method	#Instruments	DF	Beta	p-value	Beta	p-value	Beta	p-value	Beta	p-value	Beta	p-value
ADHD	Inverse variance weighted	6	5	−0.521	0.031	−0.407	0.010	−0.029	0.553	−0.209	0.144	0.028	0.292
ADHD	MR Egger Intercept	6	4	−0.080	0.267	−0.073	0.041	−0.025	0.161	−0.044	0.393	−0.004	0.679
ADHD	MR Egger	6	4	0.290	0.679	0.336	0.264	0.223	0.215	0.236	0.649	0.071	0.521
ADHD	Weighted median	6	5	−0.414	0.042	−0.352	0.016	−0.038	0.371	−0.244	0.175	0.038	0.220
ADHD	Weighted mode	6	5	−0.429	0.143	−0.309	0.114	−0.040	0.461	−0.250	0.305	0.067	0.194
BIP	Inverse variance weighted	4	3	0.083	0.297	0.087	0.246	−0.029	0.493	−0.137	0.197	−0.001	0.933
BIP	MR Egger Intercept	4	2	0.008	0.881	0.048	0.272	−0.026	0.359	−0.069	0.318	0.002	0.846
BIP	MR Egger	4	2	0.035	0.918	−0.198	0.420	0.125	0.452	0.272	0.486	−0.013	0.836
BIP	Weighted median	4	3	0.090	0.324	0.052	0.408	0.003	0.916	−0.177	0.176	0.003	0.862
BIP	Weighted mode	4	3	0.147	0.305	0.044	0.615	0.015	0.649	−0.210	0.242	0.005	0.839
SCZ	Inverse variance weighted	76	75	−0.056	0.268	−0.062	0.061	0.024	0.208	0.001	0.974	0.006	0.424
SCZ	MR Egger Intercept	76	74	−0.003	0.842	−0.006	0.584	0.002	0.811	0.008	0.569	0.003	0.275
SCZ	MR Egger	76	74	−0.011	0.960	0.018	0.907	0.004	0.965	−0.107	0.583	−0.032	0.374
SCZ	Weighted median	76	75	0.011	0.830	−0.066	0.055	0.010	0.516	0.012	0.828	0.014	0.166
SCZ	Weighted mode	76	75	0.091	0.449	−0.112	0.295	−0.015	0.713	−0.008	0.953	0.026	0.333

AFB: Age at first birth. AFS: Age at first sexual intercourse. AMC: Age at menarche. AMP: age at menopause. NLB: Number of live births.
ADHD: Attention-Deficit/Hyperactivity Disorder. ASD: Autism spectrum disorder. ED: Eating disorder. BIP: Bipolar disorder. MDD: Major depressive disorder. SCZ: Schizophrenia.

Quick links

Search