Table 2 Impact of lyso-Gb3 on bacterial counts in a transverse colon microbiota sample.

From: Lyso-Gb3 modulates the gut microbiota and decreases butyrate production

Bacterial group

Baseline

Control 24 h

500 nM lyso-Gb3 24 h

p-value*

Akkermansia

6.74 ± 0.06

6.22 ± 0.10

5.91 ± 0.10

<0.001

Bacteroides

6.50 ± 0.22

7.62 ± 0.13

6.73 ± 0.10

<0.001

B. fragilis

3.78 ± 0.02

1.55 ± 0.35

5.09 ± 0.18

<0.001

Bifidobacterium

4.40 ± 0.06

4.09 ± 0.05

3.92 ± 0.10

0.003

Bilophila

6.75 ± 0.04

7.94 ± 0.09

7.96 ± 0.07

0.328

Clostridium leptum

5.26 ± 0.05

5.20 ± 0.16

4.85 ± 0.05

0.001

Blautia coccoides-Eubacterium rectale

6.80 ± 0.06

7.07 ± 0.02

6.81 ± 0.12

0.002

Enterobacteriaceae

6.76 ± 0.07

8.70 ± 0.08

8.95 ± 0.14

0.002

Enterococcus

6.19 ± 0.05

7.74 ± 0.17

8.06 ± 0.07

0.002

Faecalibacterium

7.88 ± 0.10

7.48 ± 0.06

7.53 ± 0.16

0.276

Lactobacillus

5.42 ± 0.10

4.18 ± 0.05

3.91 ± 0.06

<0.001

Prevotella

2.79 ± 0.28

3.70 ± 0.09

4.34 ± 0.32

0.002

Roseburia

3.72 ± 0.15

3.11 ± 0.08

3.33 ± 0.16

0.006

Ruminococcus

3.98 ± 0.07

3.09 ± 0.14

2.94 ± 0.18

0.074

  1. Mean ± SD of quantitative PCR counts (log copy number/mL) for the different microbial groups analyzed.
  2. *p-values for Student’s t-test between control 24 h and 500 nM lyso-Gb3 24 h.
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